Bharadia, vikram pandya and darshan modi department of pharmaceutics, b. Slideshare uses cookies to improve functionality and performance, and to provide you with relevant advertising. Dec 15, 2011 brigham md, bick a, lo e, bendali a, burdick ja, khademhosseini a. In continued quest for the more refined system, in 1980s polymermembrane technology came to be known at forefront. Microspheres are defined as solid, spherical particles ranging in size from 1 um, made up of polymeric, waxy or other protective materials. Biodegradable polymers prolongs the residence time when contact with mucous. There is accumulating evidence that different endocytic pathways merge and are connected to the same early endosome that serves as a distribution site inside the cells. Microsphere adhesives open a world of possibilities.
Small pumps operating at slow speeds and gentle mixing are preferred. Results of preliminary trials indicate that volume of crosslinking agent, time for. Conclusion microspheres have the potential to be used for targeted and controlled release drug delivery but bioadhesive microspheres has additional advantages such as efficient absorption, enhanced bioavailability of the drugs due to a high surface to volume ratio, a much more intimate contact with the mucus layer, specific targeting of drugs. Mathiowitzs work on how to engineer multiwalled microspheres might solve some of these problems. To determine mirtazapine state of matter, xray powder diffraction was employed. Get the floating microsphere a novel gastroretentive dosage form.
Despite the better toxicity profile of these antigens they are often poorly immunogenic, so adjuvant association has been explored as a strategy to obtain a potent vaccine formulation. The cell membrane is the border that surrounds a cell it monitors what goes into and out of the cell embedded in the cell membrane are receptors. Bioadhesive microspheres as a controlled drug delivery system. Development and characterization of green tea catechins and. Bioadhesive microspheres for bioavailability enhancement. Jan 29, 2004 a collection of microspheres comprising a biocompatible material for placement at or near the site of a surgical procedure to reduce the formation of scar tissue and adhesions, the microspheres having a diameter between 0. Oct 25, 2011 a system and method for reducing the number of inputoutput connections required to connect a microfluidic substrate to an external controller for controlling the substrate. Overvi ew and recent a dvances devarshi brahmbhat t department of pharmaceutical sci ence, s chool of pharmacy, temple university, 3307 n broad st, philadelphia, pa. Biomechanical systems technology cardiovascular systems. Diclofenac sodium ds, antiinflammatory and metronidazole hydrochloride mh, antibacterial were loaded in gelatin microspheres using glutaraldehyde crosslinking.
Improvement of oral bioavailability of curcumin upon. Pharm course jss university sri shivarathreeshwara nagar mysore 570 015 jss university sri shivarathreeshwara nagar mysore 570 015 bachelor of pharmacy b. About 10 mg of the drugloaded microspheres were placed in 30 ml of buffer solution and stirred vigorously for 48 h to extract drug from the microspheres. Pharm course regulations these regulations shall be called as the regulations for the b. Core microspheres showed better mucoadhesion compared to coated microspheres when applied to the mucosal surface of freshly excised goat colon. An approach to controlled release dosage form ahmed, maizbha uddin, mahmood, sharif, islam, mohammad safiqul on. A solution of chitosan or thiolated chitosan 2% wv was prepared in acetic acid 2% vv and aqueous solution of drug 0. Library closed until further notice in order to prevent the further spread of covid19 coronavirus, the tib is closed.
Methods and material for containment and cleaning up. A well designed controlled drug delivery system can overcome some of the problems of conventional therapy and enhance the therapeutic efficacy of a given drug. Microspheres constitute an important part of novel drug delivery system ndds by virtue of their small size and efficient carrier capacity. To identify ingredients currently in the food chain that may have a nanodimension, various food. These kinds of microspheres exhibit a prolonged residence time at the site of application and causes intimate contact with the absorption site and produces better therapeutic action. Applications in membrane science, biosensing, cell culture, regenerative medicine and antibacterial coatings. Surfaceinitiated polymer brushes in the biomedical field. The optimized batch of core microspheres and coated microspheres exhibited 98.
Biomechanical systems technology cardiovascular systems volume 2, author. The cumulative fin % released after 25 days was in the range 27. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat. Nasal delivery of insulin using bioadhesive chitosan gels. Floating microspheres have been gaining attention due to the uniform distribution of these multipleunit dosage forms in the stomach, which results in more reproducible drug absorption and reduced risk of local irritation. Figure 2 a drop of liquid bioadhesive spreading over a softtissue surface. Nanoparticles types, classification, characterization. The antigen is thus continuously released to antigen presenting cells 5,10. Receptors cross the membranes and act as docking stations for molecules when a specific type of molecule attaches to a receptor, a series of chemical reactions cell signaling can occur in the cell, creating a cellular response if a.
Ijariieissno23954396 vol2 issue1 2016 floating microsphere. Gently stir microspheres before each use or transfer. The apparatus and methods of the present invention are of use for the production of emulsionbased microparticles containing a biological or chemical agent. Us20150072928a1 method for the production of emulsionbased. Bioadhesive microspheres15, 16, 17 adhesion can be defined as sticking of drug to the membrane by using the sticking property of the water soluble polymers. Tamilvanan shunmugaperumal biofilm eradication and. Formulation of bioadhesive carbomer gel incorporating drugloaded gelatin microspheres for periodontal therapy k karthikeyan1, r durgadevi1, k saravanan1, k.
Physically stimulated nanotheranostics for next generation. Mucoadhesive microspheres of the novel polymer, xyloglucan, have been formulated and their performance characteristics have been systematically evaluated in vitro and in vivo. Here, we illustrate the utility of the kunjin replicon system for gene therapy. Bioadhesive drug delivery systems can be delivered through various routes like oral, nasal, ocular, and vaginal. These tailored capsules are expected to find application in diverse areas, including drug and gene delivery. Bioadhesion is the course of action which explains the interaction between an adhesive polymer naturalsynthetic with a biological substrate. References powders and granulates freeflowing powders and granulates are needed for a variety of industrial processes. Bioadhesive polymers in the form of, or as a coating on, microcapsules containing drugs or bioactive substances which may serve for therapeutic, or diagnostic purposes in diseases of the gastrointestinal tract, are described. Facile micropatterning of dual hydrogel systems for 3d models. Increasing the dopamine content results in thicker films with a concomitant reduction in the degradation kinetics. Mucoadhesive microspheres for gastroretentive delivery of. Sep 01, 2007 bharati vidyapeeth university, department of pharmaceutics, poona college of pharmacy, india. Formulation optimization and in vivo evaluation of.
Mehta road, vile parle west, mumbai, 400 056, india abstract of the various routes of drug delivery, the. North america program microspheres are discrete spherical particles ranging from 1 to 50 microns in average particle size. Publishing platform for digital magazines, interactive publications and online catalogs. Review structural and functional aspects of the liver and liver sinusoidal cells in relation to colon carcinoma metastasis katrien vekemans, filip braet elsevier po box 23. Reduction of the mucociliary clearance of peptides in the presence of such bioadhesive materials has been thought to be the primary mechanism of enhancement of their absorption from the nasal cavity 1. Ca2516107a1 a method for production of emulsionbased.
First, inclusion complex of rhcl was prepared with cyclodextrin cd and then the complex was formulated as bioadhesive microspheres, using different proportions of carbopol cp and hpmc. Results revealed that the optimum microspheres displayed an amended sustained release pattern with lower initial burst. Eudragit s100 coated sodium alginate microspheres of. West laval, quebec canada h7l 4a8 address of principal executive offices zip code 5147446792 registrants telephone number, including area code. Microspheres tend to rise to the top of their container. Bioadhesive microspheres as sustained release drug delivery system. A read is counted each time someone views a publication summary such as the title, abstract, and list of authors, clicks on a figure, or views or downloads the fulltext. To formulate carbomer gel to localize and target drug action in periodontal pockets. Microspheres, in general, have the potential to be used for targeted and controlled release drug delivery.
Fillable online issn 2230 8407 gastroretentive dosage forms. Mathematical modeling of deposition and disposition of drugs. Bioadhesive microspheres as a controlled drug delivery. The api will be released close to the site of action with a consequent enhancement of bioavailability mucoadhesive drug delivery systems provide a means of enhancing retention at defined sites, if systemic uptake occurs the use of mucoadhesive polymers will. Development and characterization of green tea catechins and ciprofloxacinloaded nanoemulsion for intravaginal delivery to treat urinary tract infection k. Us6217908b1 bioadhesive microspheres and their use as. Pharmaceutical technology, journal of pharmacy and. Preparation of floating microspheres floating microspheres were prepared by. Hpmc and eudragit s 100 were received as a gift samples from glukem pharmaceuticals p ltd, india.
The list of invited speakers includes several world leaders in their fields, and several speakers will be selected among the best abstracts. Recently, mast cell activators were recognized as a new class of vaccine adjuvants capable of potentiating mucosal and systemic immune responses. Identification of nanomaterials in the food chain methods. Curcumin was a gift sample from krish enteprizes, mumbai, india. The polymeric microspheres all have a bioadhesive force of at least 11 mncm 2 110 nm 2. Microparticles showed good muco and bioadhesive properties, which reflected into an improved in vivo oral bioavailability of cur, ensuring higher plasma concentrations of the drug for a longer time, than those measured after the administration of the neat drug, and thus advocating a prolonged clinical significance of this drug. Dopaminemediated continuous assembly of biodegradable capsules. Formulation and evaluation of mucoadhesive glipizide. Natural polymers such as starch are used with the concept that they are biodegradable, biocompatible, and also bioadhesive in nature. To achieve maximum therapeutic efficacy, it becomes necessary to deliver the agent to the target tissue in the optimal. Microspheres constitute an important part of these particulate drug delivery systems by virtue of their small size and efficient carrier capacity, but coupling of bioadhesive properties to these microspheres has additional advantages such as prolong residence time of the dosage form at the site of absorption and intimate contact of the dosage. Dec 18, 2008 we have recently developed a noncytopathic rna repliconbased viral vector system based on the flavivirus kunjin. Microspheres act as protease inhibitors by protecting the encapsulated insulin from enzymatic degradation within its matrix as well as permeation enhancers by effectively crossing the epithelial layer after oral administration 129. The morphological characteristics of the microspheres were defined using scanning.
Compositions and methods for reducing scar tissue formation. Usha2 and m saravanan2 1vels college of pharmacy, pallavaram, chennai, india, 2jeffrey cheah school of medicine and health sciences, monash. Microspheres as a promising mucoadhesive drug delivery. For example, unpigmented or clear polyethylene microspheres supplied by cospheric in sizes from 10 micron to micron meet the quality requirements of the us fda as specified in 21 cfr 172. Release mechanism different release mechanisms figure.
Pharmaceutics free fulltext chitosan plus compound 4880. Polymeric microspheres ibiodegradable polymeric microspheres iisynthetic polymeric microspheres 1. Microspheres formulations using chitosan and thiolated chitosan as polymers were prepared using the method described by wang et al. In highly concentrated systems, the adhesive strength drops significantly. Evaluation of two novel plant gums for bioadhesive. Jens krogell, kari eranen andrey pranovic and stefan willfor o207 xylan from bleached kraft pulp isolation, modification and properties of derivatives christiane laine, antti goonroos, lauri kuutti, ali harlin and marjo maataanen 227 o208 structure and properties of composite fibers based on chitosan and chitin nanofibrils vladimir. Chapter 1 introduction bioadhesive drug to delivery. Bioadhesive microspheres have been shown to be particularly promising for the effective nasal delivery of peptides.
Preparation and characterization of microspheres for. Microfluidic devices having a reduced number of input and. Bioadhesive microspheres as sustained release drug. Magnetic microspheres are supra molecular particles that. Bioadhesive polymeric platforms for transmucosal drug. She has developed a onestep process for preparing doublewalled polymer microspheres based on phase separation between polymer mixtures, with an appropriate choice of interfacial tensions and evaporation rate, a spherical droplet of one polymer. On the other side, nonspecific bioadhesive polymers bind to both i. Glipizide microspheres containing chitosan were prepared by simple emulsification phase separation technique using glutaraldehyde as a crosslinking agent. Preparation and characterization of starchcyclodextrin bioadhesive microspheres as platform for nasal administration of gabexate mesylate foy r in allergic rhinitis treatment authors. Polyurethene, ureaformaldehyde, pmma, polystyrene 10 15 20 ncy % 0. Polystyrene microspheres and nanoparticles our polystyrene microspheres are ideal for a variety of applications microspheres are used where predictable and. A novel gastroretentive dosage form shaikh salman1, shaikh mohsin1, syed tareque2 shaikh afroz2 and fakir heena1 1aliallana college.
The adhesive work done is a sum of the surface tensions of the two adherent phases, less the interfacial tensions apparent between both phases wake, 1982. The mucoadhesive microspheres were obtained by incorporating glipizide as model drug in xyloglucan as a mucoadhesive polymer and sodium alginate as a gelforming polymer by the orificeionic gelation. Further, the process of targeting and site specific delivery with absolute accuracy can be achieved by. Process for preparation of microcapsules and microspheres 67. Gastroretentive floating microspheres are lowdensity systems that have. Development and evaluation of floating microspheres of. Contents of the powerpoint on formulation and evaluation of microspheres include.
These uniquely coded beads provide a user an addressable substrate on which to perform multiple bioanalytical reactions in a single well. Bioadhesive microspheres have advantages such as efficient absorption and enhanced bioavailability of drugs owing to a high surfacetovolume ratio, a much more intimate contact with the mucus. Techniques for the fabrication of bioadhesive microspheres, as well as a. Current vaccine research is mostly based on subunit antigens. International journal of engineering science and technology vol. The purpose of this study was to produce hollow and bioadhesive microspheres to lengthen drug retention time in the stomach. Polystyrene microspheres polystyrene nanoparticles. Environmental precautions avoid release to the environment. Due to the high biocompatibility and controllable degradation rate of hyaff microspheres they have been used for the localized delivery of steroids, analgesics, anti. Microspheres methods for preparation of microspheres. The release profile from the microspheres depends on the nature of the polymer used in the preparation as well as on the nature of the active drug. Nanovehicular intracellular delivery systems europe pmc. Avoid the destabilizing forces of highshear pumping, filtering, highspeed mixing and coating methods.
In recent time, catheterdirected hybrid magnetic microspheres based drug delivery and mriguided cancer nanotheranostics approaches have been proposed to treat cancer effeciently. Pharmatutorart1266 introduction between 1940s and 1960s, the concept of micro encapsulation technology began as an alternative means of delivering drugs. The main components of bioadhesive drug delivery systems are bioadhesive polymers. The microspheres were evaluated for drug loading, entrapment and encapsulation efficiency, particle size, drug release.
The retention of the bioadhesive radiolabelled microspheres based on hyaff was enhanced compared to the pessary formulation after 12 h of administration to the vaginal tract. Hydroxylpropylmethyl cellulose hpmc was the standard. Introduction application of ultrasonic us energy in the particle. Dehghan1, zahid zaheer1, sarfraz khan1, firoz 1 1 quality assurance technique, y.
Preparation and evaluation of glyceryl monooleatecoated. It is intended to be a forum where scientists from different areas in chemistry, physics and materials science merge to discuss about relevant aspects on those topics. Preparation of chitosan and thiolated chitosan microspheres. The purpose of this research was to formulate and systematically evaluate in vitro and in vivo performances of mucoadhesive microspheres of glipizide. Such systems have more advantages over the singleunit dosage forms. The release of drug from both biodegradable as well as nonbiodegradable microspheres is influenced by structure or micromorphology of the carrier and the properties of the polymer itself. Microspheres were produced from formulations of api and either cedrela gum fc, enterolobium gum fe or hpmc fh, using a wo solvent extraction technique. Bioadhesive and mucoadhesive polymers authorstream presentation. Mechanically robust and bioadhesive collagen and photocrosslinkable hyaluronic acid semiinterpenetrating networks. Adhesion of drug delivery device to the mucosal membrane such as buccal, ocular, rectal, nasal etc can be termed as bio adhesion. The cargo may be delivered to internal organelles caveosomes from noncaveolar uptake mechanisms sharma et al. Convert documents to beautiful publications and share them worldwide. Pgadopamine conjugates pgapda were synthesized and assembled onto silica particles to yield biodegradable capsules with tunable degradation properties.
551 1448 452 303 1467 541 46 934 76 1292 1209 934 411 958 1175 1598 1601 937 83 601 1006 1090 176 607 1539 1092 448 972 809 426 1052 1410 880 36 826 646